1984: Dr. rer. Male New Zealand White rabbits were injected intravenously with DOXO twice weekly for 8 wk [DOXO... Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres. The pathomechanisms include structural and functional changes affecting, e.g., myofiber metabolism and contractile properties. 234th ENMC International Workshop: Chaperone dysfunction in muscle disease Naarden, The Netherlands, 8-10 December 2017. Jedoch findet man molekulare Bewegungsvorgänge in allen Zelltypen. Berufserfahrung, Kontaktdaten, Portfolio und weitere Infos: Erfahr mehr – oder kontaktier Wolfgang H. Geiger direkt bei XING. Mesenchymal stromal cells (MSC) have cardiac-protective properties. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. Here, we show that diastolic dysfunction in patients with HFpEF is associated with a cardiac deficit in nicotinamide adenine dinucleotide (NAD ⁺ ). Supplemental Table for Hamdani, Herwig, Linke, Biophys Rev. SP... Alle tierischen Lebewesen, selbst Einzeller, bewegen sich fort. We generated a zebrafish model of an A-band TTNtv identified in 2... BACKGROUND:Truncating variants in the TTN gene (TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population. Cuvillier Verlag Göttingen. Although several studies in non-mammalian vertebrates have proven that extracardiac endothelial cells also participate in CoE development, the contribution of such cells to mammalian CoE is regarded to be minor and... Elucidating the biological mechanisms behind increased myocardial compliance following acute myocardial stretching and their role in cardiac diastolic (dys)function. Wolfgang König hat die Professur für Betriebswirtschaftslehre, insbesondere Wirtschaftsinformatik und Informationsmanagement an der Goethe-Universität Frankfurt inne. : 0561 7893-0. Bei Vielzellern sind die Skelettmuskeln für die Fortbewegung zuständig. Objective: In the original version of this article, the name of one of the authors is not correct. However, testing these mechanical hypotheses on proteins in their natural environment remains inaccesible to conventional tools. Aims: Cuvillier Göttingen (in Zusammenarbeit mit. MPS develops and builds scientific instruments that investigate solar system bodies. Here we show that homozygous deletion (homozygous tm1a, tm1b or tm1d alleles) of Myo18a in mouse is embryonic lethal. Zenker Ofenbackform Auflaufform mit Buch Low-Carb-Aufläufe von Wolfgang Link Mit dem 2-teiligen Set mit Ofenbackform und Low-Carb-Aufläufe Buch von Zenker können sie nicht nur tolle Rezepte nachkochen, sondern können auch noch Ihrer Traumfigur ein Stückchen näherkommen. • The extent of myocardial fibrosis and the degree of isoform-expression and phosphorylation changes in cardiomyocyte titin were unknown in different hemodynamic subgroups of AS, including “paradoxical” low-flow, low-gradient AS with preserved ejection fraction. Here, we describe a mouse model in which Z-disc-anchored TTN is depleted in adult skeletal muscles. Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.A copy of the license is included in the section entitled GNU Free Documentation License. Aims To o... Aortic Stenosis (AS) is the most frequent valvulopathy in the western world. Loslösung von Myosin-Querbrücken immer wiede... Several studies have demonstrated that administration of doxorubicin (DOXO) results in cardiotoxicity, which eventually progresses to dilated cardiomyopathy. Finde 12 Profile von Wolfgang Link mit aktuellen Kontaktdaten ☎, Lebenslauf, Interessen sowie weiteren beruflichen Informationen bei XING. Here, we characterise the molecular stru... Background The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein titin, which is a scaffolding filament, signaling platform, and provider of passive tension and elasticity in myocytes. We previously reported that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients with a dilated cardiomyopathy (DCM) mutation, troponin T (TnT)-R173W, display sarcomere protein mi... Dysfunctional high-density lipoprotein (d-HDL) in chronic kidney disease is known to have a change in composition towards an endothelial-damaging phenotype, amongst others, via the accumulation of symmetric dimethylarginine. We used hetero‐ and homozygous R349P desmin... Background 1985 - 1989: ... A current and ongoing project is to link invariants from low-dimensional topology such as the Thurston norm and the Thurston polytope to generalized -torsion invariants. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Reinshof, REPORT, EUFABA N. Metayer '04 V. faba for sust. Using intravit... Background: application of PLacenta-eXpanded (PLX) MSC-like cells (PLX) improves LV diastolic relaxation in streptozotocin (STZ)-induced diabetic mice and i... Myopathies encompass a wide variety of acquired and hereditary disorders. Familial atrial septal defect (ASD) has previously been attributed primarily to mutations in cardiac transcription factors. Bar graphs represent the mean ± SEM of splenic (A) CCR2, (B) MCP-1, (C) CX3CR1, and (D) CX3CL1 gene expression, as indicated, after normalization to the housekeeping gene 18S using the 2−ΔCt formula and normalized to the WT group, wh... Heterozygous variants in BICD cargo adapter 2 (BICD2) cause autosomal dominant spinal muscular atrophy, lower extremity-predominant 2 (SMALED2). Die Universitätsmedizin Göttingen (UMG) ist Ihr Ansprechpartner für medizinische Versorgung, Lehre und Forschung auf höchstem Niveau. Academician at Göttingen Academy of Sciences, Fellow of the International Society for Heart Research (ISHR), Franz Maximilian Groedel Research Prize of the German Cardiac Society, Heisenberg Fellowship from German Research Foundation. Wolfgang Rode Innenarchitekt in Göttingen im Branchenbuch von meinestadt.de - Telefonnummer, Adresse, Stadtplan, Routenplaner und mehr für Wolfgang Rode Innenarchitekt Göttingen Richtige Adressen und Telefonnummern finden! Join ResearchGate to contact this researcher and connect with your scientific community. Professor Dr. Wolfgang Link, Abteilung Zuchtmethodik der Pflanze, Carl-Sprengel-Weg 1, 37075 Göttingen 96 Einträge zu Wolfgang Link mit aktuellen Kontaktdaten, Öffnungszeiten und Bewertungen ☎ Das Telefonbuch - Ihre Nr. Rathaus. Participation in “Cells in Motion” Research interests: muscle cytoskeletal dynamics, biomolecular and cellular force measurements, atomic force microscopy, cardiomyocyte contractility and elasticity in health and disease, induced pluripotent stem cell-derived cardiomyocytes Papers in the research focus “cell dynamics and imaging” papers by Wolfgang A. Linke Leben. We show extensive translational control of cardiac gene expression, which i... Randomized clinical trials initially used heart failure (HF) patients with low left ventricular ejection fraction (LVEF) to select study populations with high risk to enhance statistical power. The elasticity of muscle is principally determined by the I-band region of titin, consisting of 40-100 immunoglobulin-like (Ig) domains and : You are free: to share – to copy, distribute and transmit the work; to remix – to adapt the work; Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. Universität Göttingen. Imbalances in protein homeostasis caused by mutant desmin, 234th ENMC International Workshop: Chaperone dysfunction in muscle disease, December 8-10th 2017, Naarden, Netherlands, A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance. Only verified researchers can join ResearchGate and send messages to other members. 1. Band aus Göttingen. ll Wolfgang Link gesucht? Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. So-called ‘desminopathies’ are disorders due to pathogenic variants in the DES gene and are associated with skeletal myopathies and/or various types of cardiomyopathies. We argue that, by comparing tissues from failing human hearts with age-matched non-fail... Studies on inflammatory disorders elucidated the pivotal role of the CX3CL1/CX3CR1 axis with respect to the pathophysiology and diseases progression. Auf LinkedIn können Sie sich das vollständige Profil ansehen und mehr über die Kontakte von Wolfgang Link und Jobs bei ähnlichen Unternehmen erfahren. Kontakte Fraktion Göttinger Linke . The giant protein titin is thought to be required for sarcomeric integrity in mature myocytes, but direct evidence for this hypothesis is limited. Coxsackievirus B3 (CVB3)-induced myocarditis is associated with severe cardiac inflammation, which may progress to heart failure. 205 likes. Here, we ha... Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease. Traditionally aortic valve replacement (AVR) has been recommended immediately after the onset of heart failure (HF) symptoms. We hypothesized that angiopoietin-2 (Angpt-2), antagonist of the endothelium-stabilizing receptor Tie2, induces a rapid loss of the eGC in human sepsis. Universitätsmedizin Göttingen Klinik für Neurologie Robert-Koch-Straße 40 37075 Göttingen . Various professional articles, publications and lectures on general corporate law related issues as well as capital markets subjects. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors, such as the chaperone Hsp90. Publications. Mitochondrial function is critically dependent on the folding of the mitochondrial inner membrane into cristae; indeed, numerous human diseases are associated with aberrant crista morphologies. Here, we use a novel titin-cleavage (TC) mouse model that allows specific and rapid cutting of elastic titin to quantify how titin-based forces define myocyte ultrastructure and mechanics. Sehen Sie sich die Profile von Fach- und Führungskräften namens „Wolfgang Link“ auf LinkedIn an. In the Western countries cardiovascular disease and cancer are the leading causes of death in the ageing population. Experimental data indicate that stimulation of the nitric oxide-soluble guanylate cyclase(sGC)-cGMP-PKG pathway can increase left ventricular (LV) capacitance via phosphorylation of the myofilamental protein titin. Traditional force spectroscopy of titin can study only eight tandem Ig domains at a time, and the dominant Fraktion Göttinger Linke Neues Rathaus, Zi. For the first time, we report a highly controllable viral expression model based on an iPS-cell line from a healthy human donor. 930/931 (9.Stock) Hiroshimaplatz 1-4 37083 Göttingen Telefon 05 51-4 00 23 47 Webseiten der Georg-August-Universität Göttingen. PmtA catalyzes the successive three-step N -... Background: -Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modelling, drug screening, and heart repair. nat., University of Göttingen. Rudolf-Schwander-Str. Ahmed Sallam, 2014: Detailed genetic approach to improve frost tolerance of German winter faba beans. The giant sarcomere protein titin is important in both heart health and disease. 2017 Sep 15;5(1):72. doi: 10.1186/s40478-017-0474-0, Titin phosphorylation by protein kinase G as a novel mechanism of diastolic adaptation to acute load, Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes, The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease, CX3CR1 knockout aggravates Coxsackievirus B3-induced myocarditis, P1582Dietary spermidine ameliorates hypertension and prevents diastolic dysfunction in Dahl salt-sensitive rats, Phenotypic extremes of BICD2-opathies: From lethal, congenital muscular atrophy with arthrogryposis to asymptomatic with subclinical features. We hypothesized that diminished LA compliance and contractile function occur early during the development of heart failure with preserved ejection fraction (HFpEF) and impair overall cardiac performance. Im Wintersemester 1921/22 wurde Pauli planmässiger Assistent von Professor Max Born (Link verlässt diese Seite).Born kehrte in diesem Jahr an seine Alma Mater zurück, an der er sich bereits 1909 habilitiert hatte. Fax: 0561 7893-1311. Die Telefonnummer 0551 9 48 00 finden Sie ganz oben auf der Seite. We investigated newly generated immortalized heterozygous and homozygous R349P desmin knock‐in myoblasts in conjunction with the corresponding desminopathy mice as models for desminopathies to analyse major protein quality control processes in response to the presence of R349P mutant desmin. Mustapha Arbaoui, 2007: Detailed genetic analysis of faba bean, Lamiae Ghaouti, 2007: Comparison of pure line cultivars with synthetic cultivars in local breeding of faba bean (, Susanne Dieckmann geb. We therefore investigated the influence of CX3CR1 ablation in the mode... Regulation of chemokine receptors and the corresponding chemokines in the spleen of Coxsackievirus B3-infected mice. Er leitete von 1977 bis 2014 das Institut für Humangenetik der Medizinischen Fakultät der Universität Göttingen. entropic effect of the massive native titin polypeptide is lost. Research focus on the solar system with its planets and moons, comets and asteroids, and of course the Sun. Aims: The heart is constantly challenged with acute bouts of stretching or overload. Crucial role of protein kinase G in regulating Ca2(+)/calmodulin-dependent protein kinase-II activity and oxidative stress: The diastolic function modulation via PKG-dependent CaMKII phosphorylation and oxidation. Band aus Göttingen. Cooperation with IAV Hassan II (, Reproductive features and vicine content of faba bean (, Drought tolerance, marker application, faba bean (, Awadallah Abdalla Abdelmula, 1999: Genetic improvement of drought tolerance in faba beans, Hilke M. Riemer, 1999: Nmin nach Ernte: Genotypische Variation in aktiuellem Material von Ackerbohnen (, Jens Christian Vaupel, 1999: Neue CMS-Systeme für die Produktion von Minor x Major-Hybridsorten bei, Memen Surahman, 2001: Detailed genetic analysis of a wide faba bean (, Anja Kramer, 2002: Untersuchungen zum biotechnologisch unterstützten Gentransfer bei der Ackerbohne, Andi Wijaya, 2003: Towards interspecific hybridization in, Mahmoud Mohamed Zeid, 2003: Analysis of genetic diversity based on molecular markers (AFLP) and of heterosis in faba bean (. Friedhof Junkerberg Heinrich-A.-Zachariä-Bogen 12 37077 Göttingen Kontakt: Telefon: 0551/400-5210 Telefax: 0551/400-5222 E-Mail: w.giesse@goettingen.de Whether TTNtv are sufficient to cause DCM or require a second hit for DCM manifestation is an important clinical issue. Accordingly, regulated protein decay is critical to maintain cardiac function. Erstes Album [wolf:gang] 25.08.18 Whereas myosin 18B (Myo18B) is known to be a critical sarcomeric protein, the function of myosin 18A (Myo18A) is unclear, although it has been implicated in cell motility and Golgi shape. Anbieter: Volksbank Kassel Göttingen eG. Die Staatsanwaltschaft Göttingen sieht mit Blick auf die Akten über „Linksmotivierte“ keinen Anfangsverdacht bei Mitarbeitern des Göttinger Staatsschutzes. März 1949 geboren. Daniel Siebrecht-Schöll, 2019: Breeding analysis of eight winter faba bean genotypes for mixed cropping with winter wheat. To date, the role of this interaction in the stress response of muscle remains poorly understood. Here we demonstrate that deficiency of SPRED2, an intracellular repressor of ERK-MAPK signaling markedly expressed in human heart, resulted in impaired autophagy, heart failure, and shortened lifespan. Wolfgang. Rationale: The established viral model system enables a dose-dependent and highly localized RNA-virus expression in a fully... Filamin C (FLNc) is mainly expressed in striated muscle cells where it localizes to Z-discs, myotendinous junctions and intercalated discs. Recent work suggests that the titin spring contributes to muscle contraction in a more active manner than previously thought. Seif Eldin Gasim, 2003: Winter-hardy faba bean: Applied genetic research on the reproductive mode of the European gene pool. Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy, Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes, The Impact of cGMP-PKG Pathway Modulation on Titin Phosphorylation and Titin-Based Myocardial Passive Stiffness, Membrane Remodeling by a Bacterial Phospholipid-Methylating Enzyme, Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair, Mechanically Unfolded Titin Immunoglobulin Domains Refold Faster and More Accurately in Presence of Chaperone Alpha-B-Crystallin, A Multi-Tool Mouse Model to Study the Elasticity of Native Titin, Dietary spermidine for lowering high blood pressure, Titin-truncating variants affect heart function in disease cohorts and the general population, Cardioprotection and lifespan extension by the natural polyamine spermidine, Expanding the phenotype of BICD2 mutations toward skeletal muscle involvement, Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure With Preserved Ejection FractionClinical Perspective, Developmental Basis of Cardiac Inherited Diseases470Extracardiac endothelium patterns embryonic coronary arterio-venous connections471DCM-associated RBM20-mutations lead to aberrant splicing of titin and ryanodin receptor 2 in the human myocardium472The impact of missense versus nonsense mutations in arrhythmogenic cardiomyopathy phenotype, Expression and function of dipeptidyl peptidases. All rights reserved. Loop is the open research network that increases the discoverability and impact of researchers and their work. Truncating variants in the TTN gene (TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population. 1984 - 1989 Universities of Tübingen, Munich and Göttingen, law studies. Highlights The last decade has seen enormous progress in our understanding of how titin molecular elasticity is modulated in a dynamic manner to help cardiac sarcomeres adjust to the varying hemodynamic demands on the heart... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. Systolic adaptations to these challenges are known but adaptations in diastolic stiffness remain unknown. Wolfgang Victor Ruttkowski is a scholar of literature and culture. The present work aimed to evaluate the early myocardial changes of DOXO-induced cardiotoxicity. Elevating NAD ⁺ by oral supple... Striated muscle responds to mechanical overload by rapidly up-regulating the expression of the cardiac ankyrin repeat protein, CARP, which then targets the sarcomere by binding to titin N2A in the I-band region. The prevalance of diastolic dysfunction is higher in females and associates with multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC), and diabetes mellitus (DM). Left atrial (LA) compliance and contractility influence left ventricular stroke volume. Sehen Sie sich das Profil von Wolfgang Link im größten Business-Netzwerk der Welt an. Methods Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertrophy, and remodeling. The endothelial glycocalyx, a carbohydrate-rich layer lining the endothelial luminal surface, is a first line defense against... Background: Increased titin-dependent cardiomyocyte tension is a hallmark of heart failure with preserved ejection fraction (HFpEF) associated with type-2 diabetes mellitus (T2DM). Professor of Physiology and Department Chair, Adjunct Professor of Cardiac Mechanotransduction, Professor and Chair of Cardiovascular Physiology, Titin Gene and Protein Functions in Passive and Active Muscle, Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes, Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin, Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx), Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle, Nicotinamide for the treatment of heart failure with preserved ejection fraction, Graded Titin Cleavage Uncovers the Protein's Role for Sarcomere Structure and Force Generation of Contracting Muscle, Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism, Functional characterization of novel alpha-helical rod domain desmin (DES) pathogenic variants associated with dilated cardiomyopathy, atrioventricular block and a risk for sudden cardiac death, The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease, Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation, Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs.